Research Interests: Research interests broadly focus on establishing safe and effective dosing regimens (pharmacodynamic, pharmacokinetic and clinical trial studies) of therapeutic agents in animals. Dr. Boothe’s primary emphasis is on dogs and cats, followed by exotic/wildlife/zoo [ZEW] animals and to a lesser degree, large animals (horses). This broad research interest leads to studies at all levels including molecular (e.g., mechanisms of antimicrobial resistance and virulence, inhibition of inflammatory signals), cellular (uptake of antibiotics by phagocytic cells), organ (differences in hepatic drug metabolizing enzymes among ZEW species), systems (improving drug delivery to the skin versus urinary tract) and whole animal (e.g., novel drug delivery systems). Techniques used to support these studies likewise range from molecular (PCR, RT-PCR) to analytical (HPLC/MS) to ex-vivo (tissue slice) to whole animal (models of inflammation, randomized controlled clinical trials).
Teaching Responsibilities: Presently Dr. Boothe is assisting in teaching Veterinary Pharmacology to second year veterinary students and Clinical Pharmacology to the third year students; she also participates in several systems courses. She also offers a graduate course in Clinical Pharmacology, and provides rounds in clinical pharmacology to 4th year clinical students. Dr. Boothe has a joint appointment with the Department of Clinical Sciences through which she provides patient management support in drug therapy.
Service Responsibilities: Dr. Boothe is Director of the Clinical Pharmacology Laboratory which offers a therapeutic drug monitoring service to state, national and international veterinary practices.