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Dawn M. Boothe, DVM, MS, PhD

Professor of Physiology and Pharmacology, joined the College of Veterinary Medicine in 2003. She received her B.S. degrees in Zoology (1977) and Veterinary Medicine (1978); DVM degree (1980); and MS degree in Physiology (1986) all from Texas A&M University. She continued her education with an internship in 1981 at Auburn University's Small Animal Surgery and Medicine, then went back to Texas A&M University, Small Animal Internal Medicine for residency program in 1985. Dr. Boothe completed her Ph.D. degree and fellowship, in 1989 in the field of Physiology (Clinical Pharmacology), at Texas A&M University. Dr. Boothe is a Diplomate ACVIM (Internal Medicine) and Diplomate ACVCP (Clinical Pharmacology).  Dr. Booth has received the Distinguished Achievement Award in Teaching (University Level), May 1997 and the Merck AgVet Award for Creativity in Teaching, July 1996, at Texas A&M University. Presently Dr. Booth is assisting in teaching Veterinary Pharmacology to 2nd year veterinary students and is the Director of the Clinical Pharmacology Laboratory at Auburn University's College of Veterinary Medicine.

Research Interests

Research Interests:  Research interests broadly focus on establishing safe and effective dosing regimens (pharmacodynamic, pharmacokinetic and clinical trial studies) of therapeutic agents in animals. Dr. Boothe’s primary emphasis is on dogs and cats, followed by exotic/wildlife/zoo [ZEW] animals and to a lesser degree, large animals (horses). This broad research interest leads to studies at all levels including molecular (e.g., mechanisms of antimicrobial resistance and virulence, inhibition of inflammatory signals), cellular (uptake of antibiotics by phagocytic cells), organ (differences in hepatic drug metabolizing enzymes among ZEW species),  systems (improving drug delivery to the skin versus urinary tract) and whole animal (e.g., novel drug delivery systems). Techniques used to support these studies likewise range from molecular (PCR, RT-PCR) to analytical (HPLC/MS) to ex-vivo (tissue slice) to whole animal (models of inflammation, randomized controlled clinical trials).

Teaching  Responsibilities:  Presently Dr. Boothe is assisting in teaching Veterinary Pharmacology to second year veterinary students and Clinical Pharmacology to the third year students; she also participates in several systems courses. She also offers a graduate course in Clinical Pharmacology,  and provides rounds in clinical pharmacology to 4th year clinical students.  Dr. Boothe has a joint appointment with the Department of Clinical Sciences through which she provides patient management support in drug therapy.

Service Responsibilities: Dr. Boothe is Director of the Clinical Pharmacology Laboratory which offers a therapeutic drug monitoring service  to state, national and international veterinary practices.

Selected Publications

Rees CA, Boothe DM, Boeckh A, Wilkie S, Esparza T, Green R. Dosing regimen and hematologic effects of pentoxifylline and its active metabolites in normal dogs. Vet Ther 4(2):188-196, 2003.

Neerman MF, Boothe DM. A possible mechanism of gastrointestinal toxicity posed by mycophenolic acid. Pharmacol Res 47(6):523-526, 2003.

Junkins K, Boothe DM, Jensen J, Herzog T, Chatfield J. Disposition of sulfadimethoxine in male llamas (Llama glama) after single intravenous and oral administrations. J Zoo Wildl Med 34(1):9-15, 2003.

Boothe DM, George KL, Couch P. Disposition and clinical use of bromide in cats. J Am Vet Med Assoc 15;221(8):1131-1135, 2002.

Boothe DM, Boeckh A, Boothe HW, Wilkie S, Jones S. Plasma concentrations of enrofloxacin and its active metabolite ciprofloxacin in dogs following single oral administration of enrofloxacin at 7.5, 10, or 20 mg/kg. Vet Ther 3(4):409-419, 2002.

Blanchard TL, Woods JA, Brinsko SP, Varner DD, Boothe DM. Theriogenology question of the month. Treatment options for erosive seminal vesiculitis caused by Acinetobacter calcoaceticus. J Am Vet Med Assoc 15:221(6):793-795, 2002.

Lohmann KL, Bahr A, Cohen ND, Boothe DM, Roussel AJ. Evaluation of acetaminophen absorption in horses with experimentally induced delayed gastric emptying. Am J Vet Res Feb;63(2):170-174, 2002.

Chatfield J, Jensen J, Boothe D, Herzog T, Junkins K. Disposition of sulfadimethoxine in camels (Camelus dromedarius) following single intravenous and oral doses. J Zoo Wildl Med 32(4):430-435, 2001.

Zoran DL, Boeckh A, Boothe DM. Hyperactivity and alopecia associated with ingestion of valproic acid in a cat. J Am Vet Med Assoc 15;218(10):1587-1589, 1580, 2001.

Carroll GL, Boothe DM, Hartsfield SM, Martinez EA, Spann AC, Hernandez A. Pharmacokinetics and pharmacodynamics of butorphanol in llamas after intravenous and intramuscular administration. J Am Vet Med Assoc 219(9):1263-1267, 2001.

Boeckh A, Boothe DM, Wilkie S, Jones S. Time course of enrofloxacin and its active metabolite in peripheral leukocytes of dogs. Veterinary Therapeutics 2:334-344, 2001.

Boothe DM, Boeckh A, Boothe HW, et al. Tissue concentrations of enrofloxacin and ciprofloxacin in anesthetized dogs following single intravenous administration. Vet Ther 2:120-128, 2001.

Howe LM, Boothe DM, Slater MR, Boothe HW, Wilkie S. Nitric oxide generation in a rat model of acute portal hypertension. Am J Vet Res Oct;61(10):1173-1177, 2000.

Franks JN, Boothe HW, Taylor L, Geller S, Carroll GL, Cracas V, Boothe DM. Evaluation of transdermal fentanyl patches for analgesia in cats undergoing onychectomy. J Am Vet Med Assoc Oct 1;217(7):1013-1020, 2000.

Howe LM, Boothe HW Jr, Miller MW, Boothe DM. A canine model of multiple portosystemic shunting. J Invest Surg Jan-Feb;13(1):45-57, 2000.

Lohmann KL, Roussel AJ, Cohen ND, Boothe DM, Rakestraw PC, Walker MA.  Comparison of nuclear scintigraphy and acetaminophen absorption as a means of studying gastric emptying in horses. Am J Vet Res Mar;61(3):310-315, 2000.

Carroll GL, Hooper RN, Boothe DM, Hartsfield SM, Randoll LA. Pharmacokinetics of fentanyl after intravenous and transdermal administration in goats. Am J Vet Res Aug;60(8):986-991, 1999.

Howe LM, Boothe DM, Boothe HW. Detection of portal and systemic bacteremia in dogs with severe hepatic disease and multiple portosystemic shunts. Am J Vet Res Feb;60(2):181-185, 1999.

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